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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK4 All Species: 24.85
Human Site: S243 Identified Species: 49.7
UniProt: P11802 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11802 NP_000066.1 303 33730 S243 D D W P R D V S L P R G A F P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001116412 303 33725 S243 D D W P R D V S L P R G A F P
Dog Lupus familis XP_538252 303 33686 S243 D D W P R D V S L P R G A F S
Cat Felis silvestris
Mouse Mus musculus P30285 303 33732 S243 D D W P R E V S L P R G A F A
Rat Rattus norvegicus P35426 303 33780 S243 D D W P R E V S L P R G A F S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001007893 326 36832 A248 E D W P N D V A L P R N A F A
Frog Xenopus laevis Q91727 319 35666 T243 E E W P V D V T L P R S A F S
Zebra Danio Brachydanio rerio NP_001071245 297 33310 T240 P A E D Q W P T D V T L S H H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_391955 457 50351 S400 G E W P E N V S L S W T A F P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_999689 373 42086 A248 E D Q W P D V A L P W S S F R
Poplar Tree Populus trichocarpa
Maize Zea mays P23111 294 33816 P235 W P G V S C L P D F K T A F P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 P235 W R G V T S L P D Y K S A F P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.6 97 N.A. 94.7 95 N.A. N.A. 65.3 72 71.9 N.A. N.A. 35.2 N.A. 48.7
Protein Similarity: 100 N.A. 99.6 97.6 N.A. 97 97.3 N.A. N.A. 75.7 79.9 80.1 N.A. N.A. 50.3 N.A. 60.8
P-Site Identity: 100 N.A. 100 93.3 N.A. 86.6 86.6 N.A. N.A. 66.6 60 0 N.A. N.A. 53.3 N.A. 40
P-Site Similarity: 100 N.A. 100 93.3 N.A. 93.3 93.3 N.A. N.A. 80 80 20 N.A. N.A. 66.6 N.A. 60
Percent
Protein Identity: N.A. 43.8 N.A. 45.5 N.A. N.A.
Protein Similarity: N.A. 62.7 N.A. 64 N.A. N.A.
P-Site Identity: N.A. 20 N.A. 20 N.A. N.A.
P-Site Similarity: N.A. 33.3 N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 0 0 0 0 17 0 0 0 0 84 0 17 % A
% Cys: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % C
% Asp: 42 59 0 9 0 50 0 0 25 0 0 0 0 0 0 % D
% Glu: 25 17 9 0 9 17 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 9 0 0 0 92 0 % F
% Gly: 9 0 17 0 0 0 0 0 0 0 0 42 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 9 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 17 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 17 0 75 0 0 9 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 9 9 0 0 0 0 0 9 0 0 0 % N
% Pro: 9 9 0 67 9 0 9 17 0 67 0 0 0 0 42 % P
% Gln: 0 0 9 0 9 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 9 0 0 42 0 0 0 0 0 59 0 0 0 9 % R
% Ser: 0 0 0 0 9 9 0 50 0 9 0 25 17 0 25 % S
% Thr: 0 0 0 0 9 0 0 17 0 0 9 17 0 0 0 % T
% Val: 0 0 0 17 9 0 75 0 0 9 0 0 0 0 0 % V
% Trp: 17 0 67 9 0 9 0 0 0 0 17 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _